Official microdosing safety studies: what is known

It is very difficult to fight with stereotypes that have been formed throughout our lives. That is why many of those who want to discover the world of microdosing doubt the safety of using Amanita Muscaria. After all, we have been told all our lives that this is a deadly mushroom.

In fact, you will not find recorded deaths after eating amanita mushrooms in the last 100 years of observation (earlier data were not recorded, so there is no point in discussing them). And to get mushroom poisoning, it is necessary to eat a huge amount of it raw, which, of course, no one in their right mind is going to do.

There are still few studies on the effects of red fly agaric. But we have collected for you in one place the most well-known and most reliable data about the use of the mushroom and its effect on the body.

Research and publications on the effects of red fly agaric

Even in previous centuries, scientists focused on the benefits of eating red amanita and compared it with cassava, a plant that is actively used in South America. In particular, such a similarity was discovered by the French doctor Félix Archimède Pouchet at the end of the 19th century. According to the researcher, like cassava, red fly agaric serves as a source of carbohydrates and other nutrients for the human body. But they also coincide in the need for preliminary detoxification. Before use, both red amanita and cassava must be cleaned of toxic components that can potentially cause poisoning.

At the beginning of the 21st century, the North American Mycological Association provided official information, which stated that during the previous century, not a single person who ate a red fly agaric died. The last fatal case that occurred after eating this mushroom was registered at the end of the 19th century. The dosage is conditionally considered lethal if it involves the consumption of at least 20 fresh red amanita mushrooms.

In 1980, ibotenic acid and muscimol - the main components of this mushroom - became the objects of research by many scientists. Numerous laboratory and clinical examinations have confirmed that these substances do not cause toxic or other harmful effects on the body. Therefore, "ibotenic-acid-free" fly agaric microdosing is safe for human health and life, and even useful for correcting the psycho-emotional state.

In 1993, the Japanese Institute of Nutrition presented a method of processing red amanita, which removes toxic substances from the mushroom. In modern Japan, Amanita muscaria is allowed for consumption.

In 2002, neurologists from the United States published a scientific paper on the effectiveness of microparticles containing muscimol against focal seizures caused by pilocarpine. In their work, the scientists focused on the fact that muscimol is able to reduce the intensity of seizures and reduce the severity of histological effects.

In 2009, Latvian scientists from the Faculty of Medicine of the University of Latvia conducted a study that proved the effectiveness of red fly agaric for improving cognitive functions. They presented a report in which they substantiated that muscimol is an agonist of the most important neuromodulator of the brain - gamma-aminobutyric acid. It improves the ability to remember information and learn, and therefore has the prospect of being used for the treatment of various brain dysfunctions (for example, Alzheimer's disease).

In 2018, another group of specialists conducted an experiment, the essence of which was to inject muscimol into the epileptic focus of the brain of patients suffering from drug-resistant epilepsy. The results obtained after this manipulation made it possible to conclude that ibotenic acid cannot be classified as a neurotoxin. At the same time, it was established that this component does not harm the brain parenchyma and does not interfere with the therapeutic process aimed at stopping and preventing epileptic seizures.

In 2019, toxicologists from Bulgaria presented work on the effect of Amanita muscaria extract on various models of neurotoxicity in vitro at the subcellular and cellular levels. In it, experts emphasize that muscimol is not addictive and, in particular, serves as an alternative to taking psychotropic medications (in particular, antipsychotics and antidepressants).

In 2021, specialists from a Toronto laboratory conducted a 2-week preclinical study aimed at determining the oral toxicity of fly agaric powder extract. The experiment was conducted on rats, which made it possible to obtain accurate data. The study was commissioned by Psyched Wellness Ltd. After interpreting the results of the examination, a conclusion was reached: muscimol, as it affects the body, is harmless and does not cause side effects.

In order to establish the parameters of the therapeutic window in animals, classical data were studied - weight, normal body weight gain, feed consumption, blood parameters, organ mass. After a study aimed at determining the effect of muscimol on the body, experts found that there were no complications, and every parameter studied corresponded to the norm.

Subsequently, on the initiative of the Psyched Wellness company, preclinical examinations were also conducted (end of 2021 - beginning of 2022). The duration of the study was 3 months. Its results also made it possible to confirm the harmless nature of muscimol's effect (and, accordingly, fly agaric microdosing) on the body. The conclusions drawn after this examination correspond to those obtained after the 2-week analysis. It has been established that fly agaric microdosing provides healthy, full sleep, improves the psycho-emotional state, and relieves stress.

Medicines made from Amanita Muscaria are legally used in the USA and Canada (since 2022), Denmark, the Netherlands, Italy, Japan, Norway and other countries.

Amanita Muscaria is so popular

As you can see, another surge of interest in the Amanita Muscaria (fly agaric) and its properties began at the beginning of the 21st century. There are still few studies, but all of them demonstrate the safety of the mushroom's components. In many countries, its components are used in food additives, dietary supplements and medicines. Microdosing is safe if you follow all recommendations. You can read the instructions for microdosing here, and buy Amanita Muscaria here - https://muhomornya.com